ENZYME INHIBITION

-The catalytic rate of an enzyme can be lowered by inhibitor molecules
-Many inhibitors exist including normal body metabolites, foreign drugs and toxins
-Enzyme inhibition can be divided into two main types reversible and irreversible
-Reversible inhibition can be sub-divided into competitive and non-competitive

ENZYME RESEARCH PAPER SUMMARY
Catalytic activites of lyophilized powders of a-chymotrypsin and candida lipase were found to increase 4-to-8 fold with increasing amounts of either buffer salts or potassium chloride in the enzyme preparation. When the amount of sorbitol is increased in the chymotrypsin, activity increased.
Buffers are indispensable for the transesterification activity of chymotrypsin since pertubations of pH during the reaction. With increased amounts of buffer the was significant increase. The pH changes predominant in the reactions.
Pyruvate catalyse is the predominant anaplerotic enzyme in CNS tissues, hence it provides a net utilization of glucose to generate citric cycle intermediates such as α-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, asparate and GABA